The two nations have not exchanged ambassadors since 2010 when relations began to fray under late President Hugo Chávez.
James Story’s nomination as ambassador was confirmed on Wednesday by a US Senate voice vote.
The South Carolina native takes the job that he will carry out from the capital of neighbouring Colombia as Venezuela endures an historic economic and political crisis.
The US and Venezuela have not exchanged ambassadors since 2010 when relations first started to fray under late President Hugo Chávez.
The two nations totally broke diplomatic ties last year, each withdrawing its diplomats shortly after Washington backed Venezuelan opposition leader Juan Guaidó as the country’s leader.
Story, 50, will likely play a key role in helping guide US policy on Venezuela during the transition of President-elect Joe Biden.
Biden’s win has sparked debate among those who back President Donald Trump’s hardline approach of isolating his Venezuelan counterpart Nicolas Maduro and others who say it is time for a new course.
The critics say heavy sanctions have failed to remove Maduro from power, opening Venezuela to US competitors such as China, Russia and Iran, while making life harder on millions of residents of the South American nation.
The US leads a coalition of dozens of nations that rejected Maduro following his election in 2018 to a second term in a vote Washington called fraudulent.
The US has since heavily sanctioned Maduro, his inner circle and the state-run oil firm, attempting to isolate them.
The Trump administration offered a $15m reward for Maduro’s arrest after a US court indicted him on drug charges.
